depending on how their health is, I would try a bio attack to calm it down and once it's out(dead or sleeping), you see how to possibly kill it otherwise.
now if they're 100% against any bio attack, then of course I would try the standard military gun/tank/air attacks. but seeing as that totally failed in most movies, I would try some sort of capture device from a hook to large chains or even a sort of bear trap.
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