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Originally Posted by Martian
EDIT - As so often happens, another option occured to me immediately after hitting reply. In fact, I'm feeling sort of stupid for not thinking of it earlier. Have you tried running ad-aware? If not, install the latest version and try that. If we are dealing with some sort of malware, Ad-aware may be able to pick it up and remove it.
If it doesn't (and if you haven't tried it already) I would highly recommend removing prxchk from the blacklist, as I'm reasonably sure at this point that it is in fact benign. If neither Norton or Ad-aware (both with the latest definitions, I'm assuming) pick it up, it's probably safe.
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Ad-Aware, A-squared, and Spybot are pretty good to pick up anything. A-squared is so good that it often will pick up a bunch of false positives.
Since you are using Tea Timer with spybot, why not just tell tea timer to deny the registry change and have it remember that action?
Also, are you making sure to immunize your system after every spybot update?