some 45 LC weapons will shoot .410, if they are designed for it, but I believe that the pressure differences between a shotgun shell and pistol cartridge make it dangerous in extreme to go the other way unless the gun is designed for it- it should sat .45lc/.410 or be noted in the instruction manual- as to the slug difference, I have no clue......anyone with more knowledge feel free to clarify/correct me.....
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