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This thread got me curious so I did a search on runners world web site forums, and pasted in some replies from various folks on this topic.
1: tights, tighter pants - so that my thighs cannot touch each other. If they can't touch, they don't rub.
2: a good way to prevent that is to wear fitness shorts (like bike shorts type) when you're running. try to avoid cotton, as it'll just rub through until you have a hole.
3: vaseline big time or "Body Glide" (looks like a stick of antipersperant). wicking wear is also my Godsend!
4: Body Glide is $6 - $8 a tube, so what I do is just get the gel-type X-treme Sport Right Guard and smear that on all over. I use it on my inner thighs to prevent chafing, I smear it all over my feet and in-between my toes cuz it helps keep my feet dryer and prevent blisters, hey, it works everywhere! And at $1.49 a tube, it's a lot darn cheaper than Body Glide.
5: use the body glide stuff that DD talked about. There's also some stufff called aguaphor that works really well to prevent chaffing!! If you can get a pair if running shorts from a running store or Nike outlet. The nike shorts are called drifit. This stuff is about the same as coolmax.
6: Spandex shorts. Work perfectly. No chaffing at all
7: Don't laugh I actually carry a Zip Loc bag with Vaseline (petroleum jelly) in it. I apply it when it gets uncomfortable
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