You will be traveling up the Straight of Juan de Fuca, so you shouldn't experience anything that might cause sea sickness. My sister took the trip during one of the colder months and she found it hard to breath outside. I hope you will be going during the summer season. Look for a family oriented ship so that your teens will be entertained. You might make your decision on inside v. outside rooms by how much time you plan to spend in the room.
I haven't taken the trip, but I understand that it is breathtakingly beautiful. Your wife is a lucky lady.
