Quote:
Originally Posted by gonadman
Ganglion cysts used to be treated by slamming them with a Bible- as it ruptures the cyst. Unfortunately, if the cyst ruptures, or it is aspirated with a needle, it usually returns.
The only good way to get rid of it is to surgically excise it. Once the cyst walls are gone, it can't recur. 
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Hence why they're nicknamed Biblebusters.
The wrist is a classic place to get ganglions. As said above, the only way to get it to go away permanently is surgery. Go see your doctor ASAP, especially if it's causing you significant amounts of pain.