I think it really depends on the situation. If you're looking to lose it just to say you did, then you'll be expecting some big huge reaction and you may or may not get one. Chances are though in that situation it won't have much of a lasting effect other than, well I lost it. If you're in a committed relationship and you have a strong emotional conection with the person you first have sex with, then it's only going to strengthen that bond. So in that way it changes you because you reach a new level with another person. But does just the simple act of losing your virginity in itself change you, I'd say mostly not.
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"The world is so exquisite with so much love and moral depth, that there is no reason to deceive ourselves with pretty stories for which there’s little good evidence. Far better it seems to me, in our vulnerability, is to look death in the eye and to be grateful every day for the brief but magnificent opportunity that life provides"
-Carl Sagan
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