I've been noticing the plots have seemed more disjointed than they used to, going off on tangents that barely make sense. And I agree there's been way too many of the setups, I've been loving the on-and-on jokes though, like when Stewie talks about Brian's book for 2 minutes I was rolling.
[Edit] Oh and the Herculoids was the first Family Guy reference I have ever not gotten. They went WAY back for that one though, so I have an excuse