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Engaging in an activity which may be described as anti-social in many ways leads to things like feelings of rejection, self-doubt, and anger - symptoms of depression.
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This hypothesis, though, doesn't really explain the correlation, since the correlation exists even in childhood, even before the subject is aware of it.
EDIT: to give one example, a neighbor boy (whom I teach piano) is autistic (or PDD as they call it). He's 11, and his disorder is very obvious. He also is incredibly talented musically, can learn pieces by ear more quickly than I can and is a naturally creative improvisational musician.
This is one of those demonstrated correlations, between musical creativity (in this case) and PDD.
For a well known example, check out Matthew Savage, who at 11 is an accomplished jazz pianist and has several CDs out.
http://www.wisconsinmedicalsociety.o...nt/msavage.cfm