I no longer watch the first hour of AdultSwim as I've seen all the Family Guy and Futurama episodes they show. I don't think Futurama was that good to begin with, seriously formulaic. Futurama feels like an add for "bite my metal ass" merchandise that never hit store shelves because no one cared, hollywood team writing at it's most mediocre.
Sealab has been my favorite because of the dark humor, especially the "Stim-u-tac" and "Bizarro" episodes. "Bizarro I love you Bizarro"
A lot of the anime imports alienate me at first, but then once I figure out the characters I generally end up liking them. I've even come to appreciate Case Closed which I hated at first. That show features an adult in a child body who knocks out the detective he follows around to with a dartgun to solve crimes in his voice. That's great!
Inuyasha is probably one of the most creative shows I've ever seen. The arc of the plotline is amazing once you get in to it. The various characters and monsters that populate that world all seem so unique to me. It's sad that most Americans will never get beyond their knee-jerk reaction to the show's Japanese-ness (the names, quirks, etc.).
I agree that Tom goes to the Mayor is a little disappointing so far, but I still want to see more. Robot Chicken is hilarious-again really dark humor. Robot Chicken panders heavily to my inner geek.
Milk Chan hasn't really done it for me yet. I really liked the teaser ad for it and I was excited about it but turned out different than I thought it would. I thought it would be really spastic and fast-paced, like an anime-themed
Madame Chao (epileptics beware, seriously). Instead it's more off-kilter and slow-paced. It should probably be a :15 minute show.