Shadowrun would rock.
A modern remake of Syndicate (not Syndicate Wars) would be cool.
Like Coppertop said, Steel Beasts 2 would be cool, but not likely.
Duke Nukem sequel? Please?
(might as well be in a vaporware thread)
X-wing alliance. X-wing flight sim with current day tech.
Another Monkey Island. Yes, there's been 4 of them so far, but with the current trend of adventure games going the way of the dodo, I'd want to see at least one more.
Max Payne 3? How much more pain can we put this guy through?
Eternal Darkness 2 would be cool.