you already mentioned descartes - he concluded that the only thing we can truly justify is that we exist beyond that cannot be trusted, his analogy that we could be brains in a bucket stimulted in different ways is what you are using with your matrix (I'm a little bored of that being used as an example now) analogy. I can't prove to you that your reality isn't in some way contrived - but it is what you have so why does it need to be any more complicated than that (that would satisfy Occam's law) you could drive yourself onto a paranoid mess looking for curtains hiding some ultimate truth.
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