In Resident Evil: Code Veronica, you play as Claire for the first part of the game, then switch over to Chris for the second. Right near the end, there's a part where you have to go back to Claire, so I unequipped all of Chris's guns and put them in the inventory box for Claire. Took them all out, did the short Claire bit (turns out you didn't even need any gun for it), went back to Chris and saved. All the good weapons were still in Claire's inventory though, so I didn't have anything to fight the end boss with but a pistol and a knife.
It sucked, but I happened to have a spare save that only required about a half-hour of retracing. I started saving on alternating files after a third-party memory card corrupted my FFV data. And I also ran right up to the Goldeneye guards guns blazing for about a week before I got the point.
